Ghrelin plays a minor role in the physiological control of cardiac function in the rat.

@article{Torsello2003GhrelinPA,
  title={Ghrelin plays a minor role in the physiological control of cardiac function in the rat.},
  author={Antonio Torsello and Elena Bresciani and Giuseppe Rossoni and Roberta Avallone and Giovanni Tulipano and Daniela Cocchi and Ilaria Bulgarelli and Romano Deghenghi and Ferruccio Berti and Vittorio Locatelli},
  journal={Endocrinology},
  year={2003},
  volume={144 5},
  pages={1787-92}
}
We have previously reported that a 7-d pretreatment with hexarelin, a synthetic ligand of the GH secretagogue receptor (GHS-R), largely prevented damages induced by ischemia and reperfusion in isolated rat hearts. Our aim was to ascertain whether ghrelin, an endogenous ligand of the GHS-R, is physiologically endowed with cardioprotective activity. Hypophysectomized rats were treated in vivo for 7 d with either ghrelin (320 microg/kg) or hexarelin (80 microg/kg), and their hearts were subjected… CONTINUE READING
23 Citations
29 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 29 references

Generation and characterization of ghrelin knockout mice

  • Y Sun, S Ahmed, RG Smith
  • Program of the 84th Annual Meeting of The…
  • 2002

Similar Papers

Loading similar papers…