Ghrelin is produced by the human erythroleukemic HEL cell line and involved in an autocrine pathway leading to cell proliferation.

@article{Vriese2005GhrelinIP,
  title={Ghrelin is produced by the human erythroleukemic HEL cell line and involved in an autocrine pathway leading to cell proliferation.},
  author={Carine De Vriese and Françoise Gr{\'e}goire and Philippe De Neef and Patrick Robberecht and Christine Delporte},
  journal={Endocrinology},
  year={2005},
  volume={146 3},
  pages={1514-22}
}
Ghrelin, a ligand of the GH secretagogue receptor (GHS-R 1a), is a 28-amino acid peptide with an unusual octanoyl group on Ser3, crucial for its biological activity. For the first time, ghrelin and GHS-R 1b, a truncated variant of the receptor resulting from alternative splicing, but not GHS-R 1a, mRNAs were detected in the human erythroleukemic cell line HEL. Two antibodies, used for RIA, were directed against octanoylated and total (octanoylated and desoctanoylated) ghrelin, and the… CONTINUE READING

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