• Corpus ID: 8451272

Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion.

  title={Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion.},
  author={Yukari Date and Masamitsu Nakazato and Suzuko Hashiguchi and Katsuya Dezaki and Muhtashan S. Mondal and Hiroshi Hosoda and Masayasu Kojima and Kenji Kangawa and Terukatsu Arima and Hisayuki Matsuo and Toshihiko Yada and Shigeru Matsukura},
  volume={51 1},
Ghrelin, a novel growth hormone-releasing peptide isolated from human and rat stomach, is a 28-amino acid peptide with a posttranslational acylation modification that is indispensable for stimulating growth hormone secretion by increasing intracellular Ca(2+) concentration. It also functions in the regulation of feeding behavior, energy metabolism, and gastric acid secretion and motility. Using two different antibodies against the NH(2)- and COOH-terminal regions of ghrelin, we studied its… 
Ghrelin in rat pancreatic islets decreases islet blood flow.
The results indicate a novel role for endogenous ghrelin acting directly or indirectly as a local vasoconstrictor in the islets during fasting, thereby restricting the insulin response to hyperglycemia and shows this physiological mechanism to restrict insulin delivery from the islet by acting on the vasculature is shown.
Ghrelin Is Expressed in a Novel Endocrine Cell Type in Developing Rat Islets and Inhibits Insulin Secretion from INS-1 (832/13) Cells
Ghrelin is expressed in a novel developmentally regulated endocrine islet cell type in the rat pancreas and that ghrelin inhibits glucose-stimulated insulin secretion via a direct effect on the β-cell.
Ghrelin attenuates the development of acute pancreatitis in rat.
Protective effect of ghrelin administration was found to attenuates pancreatic damage in caerulein-induced pancreatitis and the effects of both doses were similar.
The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas
Ghrelin Stimulates Insulin Secretion from the Pancreas of Normal and Diabetic Rats
Diltiazem and yohimbine failed to inhibit ghrelin‐evoked insulin release in diabetic rat pancreas, and gh Relin‐immunoreactivity cells was observed in 2.6% and 3.8% of the total cell population in the islet of Langerhans of normal and diabetic rats, respectively.
Effects of ghrelin in energy balance and body weight homeostasis
In the human body ghrelin induces a positive energy balance, an increased adiposity gain, as well as an increase in caloric storage, seen as an adaptive mechanism to caloric restriction conditions.
Modulation of Ghrelin O-Acyltransferase Expression in Pancreatic Islets
The study suggests that GOAT is present in pancreatic islet cells and that insulin inhibits the expression of GOAT via the mediation of mTOR signaling.
Final Answer: Ghrelin Can Suppress Insulin Secretion in Humans, but Is It Clinically Relevant?
Consistent with the multitude of effects of ghrelin, GHS-R1a is expressed in variety of tissues, and with regard to insulin secretion, this research area is particularly important given its potential to lead to the development of novel strategies to increase insulin secretion for the treatment of type 2 diabetes.
The effect of ghrelin on Kiss-1 and KissR gene transcription and insulin secretion in rat islets of Langerhans and CRI-D2 cell line
Findings indicate the possibility that KiSS-1 and KissR mRNA expression is mediator of ghrelin function in the islets of Langerhans.