Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells.

@article{Li2004GhrelinIP,
  title={Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells.},
  author={Wei Li and Dan Gavrila and Xuebo Liu and Lixing Wang and Skuli T. Gunnlaugsson and Lynn L. Stoll and Michael L. McCormick and Curt D. Sigmund and Chaosu Tang and Neal L. Weintraub},
  journal={Circulation},
  year={2004},
  volume={109 18},
  pages={2221-6}
}
BACKGROUND Ghrelin is a novel growth hormone-releasing peptide that has been shown to improve cachexia in heart failure and cancer and to ameliorate the hemodynamic and metabolic disturbances in septic shock. Because cytokine-induced inflammation is critical in these pathological states and because the growth hormone secretagogue receptor has been identified in blood vessels, we examined whether ghrelin inhibits proinflammatory responses in human endothelial cells in vitro and after… CONTINUE READING
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