Ghrelin inhibits insulin release by regulating the expression of inwardly rectifying potassium channel 6.2 in islets.

@article{Peng2012GhrelinII,
  title={Ghrelin inhibits insulin release by regulating the expression of inwardly rectifying potassium channel 6.2 in islets.},
  author={Zhang Zhe Peng and Zhou Xiaolei and Hani Al-Sanaban and Xue Chengrui and You Shengyi},
  journal={The American journal of the medical sciences},
  year={2012},
  volume={343 3},
  pages={
          215-9
        }
}
INTRODUCTION The objective is to investigate the influence of ghrelin administration on both the insulin secretion and the expression of ATP-sensitive K(+) channels in islet. METHODS Ghrelin and [D-Lys] growth hormone releasing peptide-6 were administered via intraperitoneal injection in Wistar rats at the doses 10 and 10 μmol/kg/d for 2 weeks, respectively. Then glucose tolerance tests were performed and plasma insulin concentrations were measured. Islets were isolated for insulin release… CONTINUE READING
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