Ghrelin increases the rewarding value of high-fat diet in an orexin-dependent manner.

@article{Perello2010GhrelinIT,
  title={Ghrelin increases the rewarding value of high-fat diet in an orexin-dependent manner.},
  author={Mario Perello and Ichiro Sakata and Shari G Birnbaum and Jen-Chieh Chuang and Sherri Osborne-Lawrence and Sherry A. Rovinsky and Jakub Woloszyn and Masashi Yanagisawa and Michael Lutter and Jeffrey M Zigman},
  journal={Biological psychiatry},
  year={2010},
  volume={67 9},
  pages={880-6}
}
BACKGROUND Ghrelin is a potent orexigenic hormone that likely impacts eating via several mechanisms. Here, we hypothesized that ghrelin can regulate extra homeostatic, hedonic aspects of eating behavior. METHODS In the current study, we assessed the effects of different pharmacological, physiological, and genetic models of increased ghrelin and/or ghrelin-signaling blockade on two classic behavioral tests of reward behavior: conditioned place preference (CPP) and operant conditioning… CONTINUE READING
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