Ghrelin improves endothelial dysfunction through growth hormone-independent mechanisms in rats.

@article{Shimizu2003GhrelinIE,
  title={Ghrelin improves endothelial dysfunction through growth hormone-independent mechanisms in rats.},
  author={Yoshito Shimizu and Noritoshi Nagaya and Yasuhiro Teranishi and Michinori Imazu and Hideya Yamamoto and Tomoki Shokawa and Kenji Kangawa and Nobuoki Kohno and Masao Yoshizumi},
  journal={Biochemical and biophysical research communications},
  year={2003},
  volume={310 3},
  pages={830-5}
}
Ghrelin is a novel growth hormone (GH)-releasing peptide which was isolated from the stomach. We have reported that ghrelin causes vasorelaxation in rats through GH-independent mechanisms. We investigated whether ghrelin improves endothelial dysfunction. Ghrelin was subcutaneously administered to GH-deficient rats for three weeks. After isolation of the thoracic aorta, aortic ring tension was measured to evaluate vasorelaxation. Acetylcholine-induced vasorelaxation was impaired in GH-deficient… CONTINUE READING