Ghrelin enhances gastric motility through direct stimulation of intrinsic neural pathways and capsaicin-sensitive afferent neurones in rats.

@article{Fukuda2004GhrelinEG,
  title={Ghrelin enhances gastric motility through direct stimulation of intrinsic neural pathways and capsaicin-sensitive afferent neurones in rats.},
  author={Hiroyuki Fukuda and Yohei Mizuta and Hajime Isomoto and Fuminao Takeshima and Ken Ohnita and Kenichi Ohba and Katsuhisa Omagari and Kohtaro Taniyama and Shigeru Kohno},
  journal={Scandinavian journal of gastroenterology},
  year={2004},
  volume={39 12},
  pages={1209-14}
}
BACKGROUND Ghrelin may stimulate gastric motility via the vagal nerve pathway. However, the mechanism of ghrelin-induced changes in gastrointestinal motility has not yet been clearly defined. The present study was designed to investigate whether ghrelin accelerates gastric emptying via capsaicin-sensitive afferent neurones and directly affects the enteric neuromuscular function. METHODS Gastric emptying of nutrient solids was assessed after intravenous administration of saline or ghrelin in… CONTINUE READING
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