Ghrelin control of GH secretion and feeding behaviour: the role of the GHS-R1a receptor studied in vivo and in vitro using novel non-peptide ligands.

@article{Bresciani2008GhrelinCO,
  title={Ghrelin control of GH secretion and feeding behaviour: the role of the GHS-R1a receptor studied in vivo and in vitro using novel non-peptide ligands.},
  author={Elena Bresciani and Laura Tamiazzo and Antonio Torsello and Ilaria Bulgarelli and Daniela Rapetti and Simona Caporali and Daniel Perrissoud and Aline Moulin and J. A. Fehrentz and Jean Mart{\'i}nez and Vittorio Locatelli},
  journal={Eating and weight disorders : EWD},
  year={2008},
  volume={13 3},
  pages={e67-74}
}
Energy homeostasis is controlled by a complex regulatory system of molecules that affect food intake and that are critical for maintaining a stable body weight during life. Ghrelin is a peptide of 28 amino acid synthesized predominantly by the stomach and the gut, which activate the type 1a growth hormone (GH) secretagogue receptor (GHS-R1a), a G-protein coupled receptor. The acylated form of ghrelin potently stimulates GH secretion both in vitro and in vivo in several animal species, including… CONTINUE READING