Ghrelin at the interface of obesity and reward.

  title={Ghrelin at the interface of obesity and reward.},
  author={Harri{\"e}t Schellekens and Timothy G Dinan and John F Cryan},
  journal={Vitamins and hormones},
The prevalence of obesity continues to increase and has reached epidemic proportions. Accumulating data over the past few decades have given us key insights and broadened our understanding of the peripheral and central regulation of energy homeostasis. Despite this, the currently available pharmacological treatments, reducing body weight, remain limited due to poor efficacy and side effects. The gastric peptide ghrelin has been identified as the only orexigenic hormone from the periphery to act… CONTINUE READING