Ghrelin and a novel preproghrelin isoform are highly expressed in prostate cancer and ghrelin activates mitogen-activated protein kinase in prostate cancer.

@article{Yeh2005GhrelinAA,
  title={Ghrelin and a novel preproghrelin isoform are highly expressed in prostate cancer and ghrelin activates mitogen-activated protein kinase in prostate cancer.},
  author={Anthony H. Yeh and Penelope L. Jeffery and Russell P. Duncan and Adrian C. Herington and Lisa Chopin},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2005},
  volume={11 23},
  pages={
          8295-303
        }
}
PURPOSE There is evidence that the hormone ghrelin stimulates proliferation in the PC3 prostate cancer cell line although the underlying mechanism(s) remain to be determined. A novel, exon 3-deleted preproghrelin isoform has previously been detected in breast and prostate cancer cells; however, its characterization, expression, and potential function in prostate cancer tissues are unknown. EXPERIMENTAL DESIGN Expression of ghrelin and exon 3-deleted preproghrelin was investigated in prostate… CONTINUE READING
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