Ghrelin alleviates cancer chemotherapy-associated dyspepsia in rodents

@article{Liu2005GhrelinAC,
  title={Ghrelin alleviates cancer chemotherapy-associated dyspepsia in rodents},
  author={Y. Liu and Nasser M. Malik and Gareth John Sanger and Paul L. R. Andrews},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2005},
  volume={58},
  pages={326-333}
}
Purpose: Chemotherapy treatment may lead to delayed gastric emptying, early satiety, anorexia, nausea and vomiting, described collectively as the cancer-associated dyspepsia syndrome (CADS). Method: We examined the effects of ghrelin in rodent models of CADS induced by treatment with cisplatin. Results: In rats, increased gastric contents and reduced feeding were observed 48 h after injection with cisplatin (6 mg/kg, i.p.). Ghrelin (0.5 mg/kg, i.p.) caused a 16-fold increase in food intake over… CONTINUE READING
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