Ghrelin affects the hypothalamus-pituitary-thyroid axis in humans by increasing free thyroxine and decreasing TSH in plasma.

@article{Kluge2010GhrelinAT,
  title={Ghrelin affects the hypothalamus-pituitary-thyroid axis in humans by increasing free thyroxine and decreasing TSH in plasma.},
  author={Michael Kluge and Stefan Riedl and M. Uhr and Doreen Schmidt and Xiaochi Zhang and A. Yassouridis and Axel Steiger},
  journal={European journal of endocrinology},
  year={2010},
  volume={162 6},
  pages={1059-65}
}
OBJECTIVE Ghrelin promotes a positive energy balance, e.g. by increasing food intake. Stimulation of the activity of the hypothalamus-pituitary-thyroid (HPT) axis promotes a negative energy balance, e.g. by increasing energy expenditure. We therefore hypothesized that ghrelin suppresses the HPT axis in humans, counteracting its energy-saving effect. DESIGN AND METHODS In this single-blind, randomized, cross-over study, we determined secretion patterns of free triiodothyronine (fT(3)), free… CONTINUE READING

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