Ghrelin Stimulates Insulin Secretion from the Pancreas of Normal and Diabetic Rats

@article{Adeghate2002GhrelinSI,
  title={Ghrelin Stimulates Insulin Secretion from the Pancreas of Normal and Diabetic Rats},
  author={Ernest A. Adeghate and Abdul Samad Ponery},
  journal={Journal of Neuroendocrinology},
  year={2002},
  volume={14}
}
Ghrelin is a novel 28‐amino acid gut–brain peptide, which was first isolated in the rat stomach. This study examined the effect of ghrelin on insulin secretion from the isolated pancreas of normal and diabetic rats. Diabetes was induced by a single dose of streptozotocin. Four weeks after the induction of diabetes, pancreatic tissue fragments of normal and diabetic rats were treated with different concentrations (10−12, 10−9 and 10−6 M) of ghrelin. Ghrelin evoked large and significant increases… 
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Mechanism of ghrelin-evoked glucagon secretion from the pancreas of diabetic rats.
TLDR
It appears that the main target of ghrelin in the rat endocrine pancreas is not glucagon-producing cells but rather insulin secreting cells which are more involve in weight gain and body growth.
DISTRIBUTION OF GHRELIN IN PANCREATIC ISLET CELLS OF NORMAL AND DIABETIC RATS AND ITS EFFECT ON DIABETES MELLITUS
TLDR
It is demonstrated that ghrelin co-localizes with insulin as well as glucagon in the pancreatic islet cells and that the pattern of gh Relin distribution is shown to alter after the onset of diabetes.
Exogenous Ghrelin Increases Plasma Insulin Level in Diabetic Rats †
TLDR
The results show that the administration of ghrelin increases the number of insulin-secreting beta cells and serum insulin level in both normal and diabetic rats, and co-localizes with insulin in the secretory granules of pancreaticBeta cells and enhances insulin production.
Effect of obestatin on insulin, glucagon and somatostatin secretion in the perfused rat pancreas
Mechanism of Orexin B-Stimulated Insulin and Glucagon Release From the Pancreas of Normal and Diabetic Rats
TLDR
Orexin B stimulated insulin secretion in normal and diabetic rat pancreas through the &bgr;-adrenergic pathway and may have an important role in the regulation of islet function.
Effect of nociceptin on insulin release in normal and diabetic rat pancreas
TLDR
The co-localization of NC with insulin suggests a role for NC in the regulation of pancreatic beta cell function.
Ghrelin infused into the portal vein inhibits glucose-stimulated insulin secretion in Wistar rats
Mechanism of ipamorelin-evoked insulin release from the pancreas of normal and diabetic rats.
TLDR
This is the first study to examine the effect of ipamorelin on insulin secretion in the pancreas, a novel pentapeptide with a strong growth hormone releasing potency, on pancreatic tissue fragments of normal and diabetic rats.
The role of ghrelin in the regulation of glucose homeostasis
TLDR
A detailed summary of recent advances in the field that focuses on the role of insulin and insulin resistance in the regulation of ghrelin secretion and in glucose-stimulated insulin secretion (GSIS) is provided.
Products of the ghrelin gene, the pancreatic β-cell and the adipocyte.
TLDR
Results from ghrelin, GHS-R and GOAT knockout mice have indicated that AG display diabetogenic effects in vivo, and a new role has been recently proposed for obestatin on adipocyte function and insulin sensitivity.
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References

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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