Ghrelin Stimulates Insulin Secretion from the Pancreas of Normal and Diabetic Rats

@article{Adeghate2002GhrelinSI,
  title={Ghrelin Stimulates Insulin Secretion from the Pancreas of Normal and Diabetic Rats},
  author={Ernest A. Adeghate and Abdul Samad Ponery},
  journal={Journal of Neuroendocrinology},
  year={2002},
  volume={14}
}
Ghrelin is a novel 28‐amino acid gut–brain peptide, which was first isolated in the rat stomach. This study examined the effect of ghrelin on insulin secretion from the isolated pancreas of normal and diabetic rats. Diabetes was induced by a single dose of streptozotocin. Four weeks after the induction of diabetes, pancreatic tissue fragments of normal and diabetic rats were treated with different concentrations (10−12, 10−9 and 10−6 M) of ghrelin. Ghrelin evoked large and significant increases… 
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TLDR
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TLDR
Findings indicate that ghrelin may regulate islet function in an endocrine and/or paracrine manner.
Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion.
TLDR
Findings indicate that ghrelin may regulate islet function in an endocrine and/or paracrine manner.
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TLDR
Intravenous administrations of rat ghrelin at 0.8 to 20 microgram/kg dose-dependently increased not only gastric acid secretion measured by a lumen-perfused method, but also gastric motility measured byA miniature balloon method suggest that gh Relin may play a physiological role in the vagal control of gastric function in rats.
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TLDR
The results suggest that ghrelin participates in the central regulation of gastric acid secretion by activating the vagus system, and Intracerebroventricular administration increases food intake and body weight.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
The effects of chronic intracerebroventricular treatment with ghrelin on metabolic factors and on neuropeptide genes that are expressed in hypothalamic neurons that have been previously shown to express the GHS-R and to regulate food consumption are determined.
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