Ghrelin Stimulates Insulin Secretion from the Pancreas of Normal and Diabetic Rats

  title={Ghrelin Stimulates Insulin Secretion from the Pancreas of Normal and Diabetic Rats},
  author={E. Adeghate and A. Ponery},
  journal={Journal of Neuroendocrinology},
  • E. Adeghate, A. Ponery
  • Published 2002
  • Chemistry, Medicine, Biology
  • Journal of Neuroendocrinology
  • Ghrelin is a novel 28‐amino acid gut–brain peptide, which was first isolated in the rat stomach. This study examined the effect of ghrelin on insulin secretion from the isolated pancreas of normal and diabetic rats. Diabetes was induced by a single dose of streptozotocin. Four weeks after the induction of diabetes, pancreatic tissue fragments of normal and diabetic rats were treated with different concentrations (10−12, 10−9 and 10−6 M) of ghrelin. Ghrelin evoked large and significant increases… CONTINUE READING
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