Ghrelin Receptor (GHS‐R1A) Agonists Show Potential as Interventive Agents during Aging

@article{Smith2007GhrelinR,
  title={Ghrelin Receptor (GHS‐R1A) Agonists Show Potential as Interventive Agents during Aging},
  author={Roy G. Smith and Yuxiang Sun and Hong Jiang and Rosie G. Albarran-Zeckler and Nikolai A. Timchenko},
  journal={Annals of the New York Academy of Sciences},
  year={2007},
  volume={1119}
}
Abstract:  Administration of an orally active agonist (MK‐0677) of the growth hormone secretagogue receptor (GHS‐R1a) to elderly subjects restored the amplitude of endogenous episodic growth hormone (GH) release to that of young adults. Functional benefits include increased lean mass and bone density and modest improvements in strength. In old mice, a similar agonist partially restored function to the thymus and reduced tumor cell growth and metastasis. Treatment of old mice with the endogenous… 
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TLDR
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The GH secretagogues act through all four mechanisms to reproduce a young adult physiological GH profile in elderly subjects that was accompanied by increased bone mineral density and lean mass, modest improvements in strength, and improved recovery from hip fracture.
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TLDR
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TLDR
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TLDR
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The data show that ghrelin is not critically required for viability, fertility, growth, appetite, bone density, and fat deposition and not likely to be a direct regulator of leptin and insulin, and antagonists of gh Relin are unlikely to have broad utility as antiobesity agents.
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