Ghrelin Octanoylation Is Completely Stabilized in Biological Samples by Alkyl Fluorophosphonates.

@article{McGovernGooch2016GhrelinOI,
  title={Ghrelin Octanoylation Is Completely Stabilized in Biological Samples by Alkyl Fluorophosphonates.},
  author={Kayleigh R McGovern-Gooch and Trevor Rodrigues and Joseph E. Darling and Michelle A Sieburg and Alfonso Abizaid and James L. Hougland},
  journal={Endocrinology},
  year={2016},
  volume={157 11},
  pages={4330-4338}
}
Ghrelin is a peptide hormone involved in multiple physiological processes related to energy homeostasis. This hormone features a unique posttranslational serine octanoylation modification catalyzed by the enzyme ghrelin O-acyltransferase, with serine octanoylation essential for ghrelin to bind and activate its cognate receptor. Ghrelin deacylation rapidly… CONTINUE READING