Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice.

@article{Zhao2010GhrelinO,
  title={Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice.},
  author={Tong-jin Zhao and Guosheng Liang and Robert Lin Li and Xuefen Xie and M W Sleeman and Andrew J. Murphy and David M. Valenzuela and George D. Yancopoulos and Joseph L Goldstein and Michael Scott Brown},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 16},
  pages={7467-72}
}
Ghrelin O-acyltransferase (GOAT) attaches octanoate to proghrelin, which is processed to ghrelin, an octanoylated peptide hormone that stimulates release of growth hormone (GH) from pituitary cells. Elimination of the gene encoding ghrelin or its receptor produces only mild phenotypes in mice. Thus, the essential function of ghrelin is obscure. Here, we eliminate the Goat gene in mice, thereby eliminating all octanoylated ghrelin from blood. On normal or high fat diets, Goat(-/-) mice grew and… CONTINUE READING
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