Ghrelin Attenuated Lipotoxicity via Autophagy Induction and Nuclear Factor-κB Inhibition.

  title={Ghrelin Attenuated Lipotoxicity via Autophagy Induction and Nuclear Factor-κB Inhibition.},
  author={Yuqing Mao and Jian Cheng and Fujun Yu and Huanqing Li and Chuanyong Guo and Xiaoming Fan},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  volume={37 2},
BACKGROUND/AIMS Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Autophagy is associated with NAFLD. Ghrelin is a gut hormone with various functions including energy metabolism and inflammation inhibition. We investigated the therapeutic effect of ghrelin on NAFLD and its association with autophagy. METHODS C57bl/6 mice were fed a high-fat diet for 8 weeks to induce a model of chronic NAFLD, with ghrelin (10 µg/kg) administrated subcutaneously twice… CONTINUE READING
21 Citations
43 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 21 extracted citations


Publications referenced by this paper.
Showing 1-10 of 43 references

autophagy-lysosomal pathway in mice. Hepatology 2014;59:1366-1380

  • M Kojima, H Hosoda, Y Date, M Nakazato, H Matsuo, K Kangawa
  • 2014

Similar Papers

Loading similar papers…