• Chemistry
  • Published 2007

Ghrelin对MPTP小鼠帕金森病模型黑质TH、Bcl-2和Bax mRNA表达的影响

  title={Ghrelin对MPTP小鼠帕金森病模型黑质TH、Bcl-2和Bax mRNA表达的影响},
  author={李林静 and 姜宏 and 王俊 and 谢俊霞},
Objective To investigate the effect of Ghrlein on tyrosine hydroxylase (TH) Bcl-2 and Bax mRNA expression of the subatantia nigra in 1-methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced mouse model of Parkinson disease. Methods Eighteen healthy male C57BL/6 mice were divided into three groups at random: Control, MPTP and Ghrelin+MPTP. The mice in MPTP group were injected with MPTP (30mg/kg. i. p.), once daily for five days, with Ghrelin (i. c. v.). 2 h before the injection of MPTP, once… CONTINUE READING