Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor.

@article{Kojima2001GhrelinDO,
  title={Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor.},
  author={Masayasu Kojima and Hiroshi Hosoda and Hisayuki Matsuo and Kenji Kangawa},
  journal={Trends in endocrinology and metabolism: TEM},
  year={2001},
  volume={12 3},
  pages={118-22}
}
Growth hormone (GH) secretagogues (GHSs) are small synthetic molecules that act through a specific G-protein-coupled receptor (GPCR) called GHS-R. Until the recent identification of 'ghrelin' from rat and human stomachs, GHS-R was an orphan receptor (i.e. had no known natural ligand). Ghrelin is a 28-amino acid peptide with an essential n-octanoyl modification at Ser3. This peptide is found in the secretory granules of X/A-like cells, whose hormonal products and physiological functions have not… CONTINUE READING