Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat.

@article{Trudel2002GhrelinmotilinrelatedPI,
  title={Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat.},
  author={L. Trudel and C. Tomasetto and M. Rio and M. Bouin and V. Plourde and P. Eberling and P. Poitras},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2002},
  volume={282 6},
  pages={
          G948-52
        }
}
A novel peptide called ghrelin or motilin-related-peptide (MTLRP) was found in the stomach of various mammals. We studied its effect on the motor function of the rat gastrointestinal tract. In normal, conscious unoperated animals, ghrelin/MTLRP (5 or 20 microg/kg iv) significantly accelerated the gastric emptying of a methylcellulose liquid solution (gastric residue after 15 min: 57 +/- 7, 42 +/- 11, 17 +/- 4, and 9 +/- 3% of the ingested meal with doses of 0, 1, 5, and 20 microg/kg iv… Expand
278 Citations

Paper Mentions

Observational Clinical Trial
The purpose of this research is to see if there are differences between children who have FD and children without FD in the ability of the stomach to empty food and/or in ghrelin… Expand
ConditionsFunctional Dyspepsia
Ghrelin and motilin in the gastrointestinal system.
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Effect of the ghrelin receptor agonist TZP-101 on colonic transit in a rat model of postoperative ileus.
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References

SHOWING 1-10 OF 30 REFERENCES
Ghrelin stimulates gastric acid secretion and motility in rats.
  • 848
In vivo and in vitro Effects of Ghrelin/Motilin-Related Peptide on Growth Hormone Secretion in the Rat
  • 163
Ghrelin elicits a marked stimulatory effect on GH secretion in freely-moving rats.
  • 230
  • PDF
Ghrelin acts in the central nervous system to stimulate gastric acid secretion.
  • 370
The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion.
  • 1,514
  • PDF
Identification of cDNA encoding motilin related peptide/ghrelin precursor from dog fundus
  • 53
Ghrelin induces adiposity in rodents
  • 3,670
Purification and Characterization of Rat des-Gln14-Ghrelin, a Second Endogenous Ligand for the Growth Hormone Secretagogue Receptor*
  • 350
  • PDF
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1
2
3
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