Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat.

@article{Trudel2002GhrelinmotilinrelatedPI,
  title={Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat.},
  author={L. Trudel and C. Tomasetto and M. C. R{\'i}o and M. Bouin and V. Plourde and P. Eberling and P. Poitras},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2002},
  volume={282 6},
  pages={
          G948-52
        }
}
  • L. Trudel, C. Tomasetto, +4 authors P. Poitras
  • Published 2002
  • Biology, Medicine
  • American journal of physiology. Gastrointestinal and liver physiology
  • A novel peptide called ghrelin or motilin-related-peptide (MTLRP) was found in the stomach of various mammals. We studied its effect on the motor function of the rat gastrointestinal tract. In normal, conscious unoperated animals, ghrelin/MTLRP (5 or 20 microg/kg iv) significantly accelerated the gastric emptying of a methylcellulose liquid solution (gastric residue after 15 min: 57 +/- 7, 42 +/- 11, 17 +/- 4, and 9 +/- 3% of the ingested meal with doses of 0, 1, 5, and 20 microg/kg iv… CONTINUE READING
    278 Citations

    Paper Mentions

    Observational Clinical Trial
    The purpose of this research is to see if there are differences between children who have FD and children without FD in the ability of the stomach to empty food and/or in ghrelin hormone… Expand
    ConditionsFunctional Dyspepsia
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