• DOI:10.1152/AJPGI.00339.2001
Corpus ID: 8934330

Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat.

@article{Trudel2002GhrelinmotilinrelatedPI,
  title={Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat.},
  author={L. Trudel and C. Tomasetto and M. C. R{\'i}o and M. Bouin and V. Plourde and P. Eberling and P. Poitras},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2002},
  volume={282 6},
  pages={
          G948-52
        }
}

L. Trudel, C. Tomasetto, +4 authors P. Poitras

Published 2002

Biology, Medicine

American journal of physiology. Gastrointestinal and liver physiology

A novel peptide called ghrelin or motilin-related-peptide (MTLRP) was found in the stomach of various mammals. We studied its effect on the motor function of the rat gastrointestinal tract. In normal, conscious unoperated animals, ghrelin/MTLRP (5 or 20 microg/kg iv) significantly accelerated the gastric emptying of a methylcellulose liquid solution (gastric residue after 15 min: 57 +/- 7, 42 +/- 11, 17 +/- 4, and 9 +/- 3% of the ingested meal with doses of 0, 1, 5, and 20 microg/kg iv… CONTINUE READING

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