Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat.

  title={Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat.},
  author={L. Trudel and C. Tomasetto and M. C. R{\'i}o and M. Bouin and V. Plourde and P. Eberling and P. Poitras},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  volume={282 6},
  • L. Trudel, C. Tomasetto, +4 authors P. Poitras
  • Published 2002
  • Biology, Medicine
  • American journal of physiology. Gastrointestinal and liver physiology
  • A novel peptide called ghrelin or motilin-related-peptide (MTLRP) was found in the stomach of various mammals. We studied its effect on the motor function of the rat gastrointestinal tract. In normal, conscious unoperated animals, ghrelin/MTLRP (5 or 20 microg/kg iv) significantly accelerated the gastric emptying of a methylcellulose liquid solution (gastric residue after 15 min: 57 +/- 7, 42 +/- 11, 17 +/- 4, and 9 +/- 3% of the ingested meal with doses of 0, 1, 5, and 20 microg/kg iv… CONTINUE READING
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