Ghrelin's role as a major regulator of appetite and its other functions in neuroendocrinology.

@article{Lim2010GhrelinsRA,
  title={Ghrelin's role as a major regulator of appetite and its other functions in neuroendocrinology.},
  author={Chung Thong Lim and Blerina P Kola and M{\'a}rta Korbonits and Ashley B. Grossman},
  journal={Progress in brain research},
  year={2010},
  volume={182},
  pages={189-205}
}
Ghrelin is a circulating growth-hormone-releasing and appetite-inducing brain-gut peptide. It is a known natural ligand of the growth hormone secretagogue receptor (GHS-R). Ghrelin is acylated on its serine 3 residue by ghrelin O-acyltransferase (GOAT). The acylation is essential for its orexigenic and adipogenic effects. Ghrelin exerts its central orexigenic effect through activation of various hypothalamic and brain stem neurons. Several new intracellular targets/mediators of the appetite… CONTINUE READING

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