Ghrelin's Role in the Hypothalamic-Pituitary-Adrenal Axis Stress Response: Implications for Mood Disorders.

@article{Spencer2015GhrelinsRI,
  title={Ghrelin's Role in the Hypothalamic-Pituitary-Adrenal Axis Stress Response: Implications for Mood Disorders.},
  author={S J Spencer and Tim L Emmerzaal and Tamas L Kozicz and Zane B Andrews},
  journal={Biological psychiatry},
  year={2015},
  volume={78 1},
  pages={19-27}
}
Ghrelin is a stomach hormone normally associated with feeding behavior and energy homeostasis. Recent studies highlight that ghrelin targets the brain to regulate a diverse number of functions, including learning, memory, motivation, stress responses, anxiety, and mood. In this review, we discuss recent animal and human studies showing that ghrelin regulates the hypothalamic-pituitary-adrenal axis and affects anxiety and mood disorders, such as depression and fear. We address the neural sites… CONTINUE READING