Gfi1aa and Gfi1b set the pace for primitive erythroblast differentiation from hemangioblasts in the zebrafish embryo.

@article{Moore2018Gfi1aaAG,
  title={Gfi1aa and Gfi1b set the pace for primitive erythroblast differentiation from hemangioblasts in the zebrafish embryo.},
  author={Chris Moore and Joanna L Richens and Yasmin Hough and Deniz Ucanok and Sudarshan R. Malla and Fei Sang and Yan Chen and Stone Elworthy and Robert N Wilkinson and Martin Gering},
  journal={Blood advances},
  year={2018},
  volume={2 20},
  pages={
          2589-2606
        }
}
The transcriptional repressors Gfi1(a) and Gfi1b are epigenetic regulators with unique and overlapping roles in hematopoiesis. In different contexts, Gfi1 and Gfi1b restrict or promote cell proliferation, prevent apoptosis, influence cell fate decisions, and are essential for terminal differentiation. Here, we show in primitive red blood cells (prRBCs) that they can also set the pace for cellular differentiation. In zebrafish, prRBCs express 2 of 3 zebrafish Gfi1/1b paralogs, Gfi1aa and Gfi1b… CONTINUE READING
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