Gfi1 and Gfi1b act equivalently in haematopoiesis, but have distinct, non-overlapping functions in inner ear development.

@article{Fiolka2006Gfi1AG,
  title={Gfi1 and Gfi1b act equivalently in haematopoiesis, but have distinct, non-overlapping functions in inner ear development.},
  author={Katharina Fiolka and R Hertzano and Lothar Vassen and Hui Zeng and Orit Hermesh and Karen B. Avraham and Ulrich D{\"u}hrsen and Tarik M{\"o}r{\"o}y},
  journal={EMBO reports},
  year={2006},
  volume={7 3},
  pages={326-33}
}
Gfi1 is a transcriptional repressor essential for haematopoiesis and inner ear development. It shares with its paralogue Gfi1b an amino-terminal SNAG repressor domain and six carboxy-terminal zinc-finger motifs, but differs from Gfi1b in sequences separating these domains. Here, we describe two knock-in mouse models, in which the N-terminal SNAG repressor domain was mutated or in which the Gfi1 coding region was replaced by Gfi1b. Mouse mutants without an intact SNAG domain show the full… CONTINUE READING