Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor.

@article{ZweidlerMckay1996Gfi1EA,
  title={Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor.},
  author={Patrick A. Zweidler-Mckay and H. Leighton Grimes and Marcella M Flubacher and Philip N Tsichlis},
  journal={Molecular and cellular biology},
  year={1996},
  volume={16 8},
  pages={
          4024-34
        }
}
The Gfi-1 proto-oncogene encodes a zinc finger protein with six C2H2-type, C-terminal zinc finger motifs and is activated by provirus integration in T-cell lymphoma lines selected for interleukin-2 independence in culture and in primary retrovirus-induced thymomas. Gfi-1 expression in adult animals is restricted to the thymus, spleen, and testis and is enhanced in mitogen-stimulated splenocytes. In this report, we show that Gfi-1 is a 55-kDa nuclear protein that binds DNA in a sequence-specific… CONTINUE READING
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