Gex1 is a yeast glutathione exchanger that interferes with pH and redox homeostasis

Abstract

In the yeast Saccharomyces cerevisiae, glutathione plays a major role in heavy metal detoxification and protection of cells against oxidative stress. We show that Gex1 is a new glutathione exchanger. Gex1 and its paralogue Gex2 belong to the major facilitator superfamily of transporters and display similarities to the Aft1-regulon family of siderophore… (More)
DOI: 10.1091/mbc.E10-11-0906

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