Getting to the center of X-chromosome inactivation: the role of transgenes.

@article{Minks2009GettingTT,
  title={Getting to the center of X-chromosome inactivation: the role of transgenes.},
  author={Jakub Minks and Carolyn J Brown},
  journal={Biochemistry and cell biology = Biochimie et biologie cellulaire},
  year={2009},
  volume={87 5},
  pages={
          759-66
        }
}
X-chromosome inactivation is a fascinating epigenetic phenomenon that is initiated by expression of a noncoding (nc)RNA, XIST, and results in transcriptional silencing of 1 female X. The process requires a series of events that begins even before XIST expression, and culminates in an active and a silent X within the same nucleus. We will focus on the role that transgenic systems have served in the current understanding of the process of X-chromosome inactivation, both in the initial delineation… CONTINUE READING

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