Getting to the bottom of Taxol biosynthesis by fungi

  title={Getting to the bottom of Taxol biosynthesis by fungi},
  author={U. Heinig and S. Scholz and S. Jennewein},
  journal={Fungal Diversity},
  • U. Heinig, S. Scholz, S. Jennewein
  • Published 2013
  • Biology
  • Fungal Diversity
  • Taxol (paclitaxel) is a highly-oxygenated diterpenoid natural product first isolated from the pacific yew tree (Taxus brevifolia). It is one of the most widely used anticancer drugs. Soon after the discovery of its unique mode of action and the resulting high demand, an extensive search was initiated for alternative sources to replace the slow-growing and scarce pacific yew. Thus far, however, Taxol and related compounds have only been found in the genus Taxus, which comprises a small number of… CONTINUE READING
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