Getting to the bottom of Taxol biosynthesis by fungi

@article{Heinig2013GettingTT,
  title={Getting to the bottom of Taxol biosynthesis by fungi},
  author={Uwe Heinig and Susanne Scholz and Stefan Jennewein},
  journal={Fungal Diversity},
  year={2013},
  volume={60},
  pages={161-170}
}
Taxol (paclitaxel) is a highly-oxygenated diterpenoid natural product first isolated from the pacific yew tree (Taxus brevifolia). It is one of the most widely used anticancer drugs. Soon after the discovery of its unique mode of action and the resulting high demand, an extensive search was initiated for alternative sources to replace the slow-growing and scarce pacific yew. Thus far, however, Taxol and related compounds have only been found in the genus Taxus, which comprises a small number of… 
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TLDR
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TLDR
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Comparative transcriptome analysis of a taxol-producing endophytic fungus, Aspergillus aculeatinus Tax-6, and its mutant strain
TLDR
The transcriptome of an endophytic fungus, Aspergillus aculeatinus Tax-6, was analyzed in order to understand the molecular mechanisms of producing fungal taxol and the potential for the construction of taxol-producing genetic engineering strains.
Taxol Origins and Production Development 2 . 1 Natural Role and Therapeutic Utilization
TLDR
This chapter focuses on the currently utilized and emerging biosynthetic options for Taxol production and a particular emphasis is placed on the biosynthesis production hosts including macroscopic and unicellular plant species and more recent attempts to elucidate, transfer, and reconstitute the Taxol pathway within technically advanced microbial hosts.
Taxol from Corylus avellana: paving the way for a new source of this anti-cancer drug
TLDR
A review of the literature suggests that C. avellana may act as a commercial and alternative source for taxol production in an eco-friendly way, which will meet the ever-increasing demand, and also help reducing the cost of this anti-cancer compound.
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