Getting to the bottom of Taxol biosynthesis by fungi

@article{Heinig2013GettingTT,
  title={Getting to the bottom of Taxol biosynthesis by fungi},
  author={U. Heinig and S. Scholz and S. Jennewein},
  journal={Fungal Diversity},
  year={2013},
  volume={60},
  pages={161-170}
}
  • U. Heinig, S. Scholz, S. Jennewein
  • Published 2013
  • Biology
  • Fungal Diversity
  • Taxol (paclitaxel) is a highly-oxygenated diterpenoid natural product first isolated from the pacific yew tree (Taxus brevifolia). It is one of the most widely used anticancer drugs. Soon after the discovery of its unique mode of action and the resulting high demand, an extensive search was initiated for alternative sources to replace the slow-growing and scarce pacific yew. Thus far, however, Taxol and related compounds have only been found in the genus Taxus, which comprises a small number of… CONTINUE READING
    128 Citations

    Figures and Tables from this paper

    Natural Sources of Taxol
    • 13
    Conjugation of Aspergillus flavipes Taxol with Porphyrin Increases the Anticancer Activity of Taxol and Ameliorates Its Cytotoxic Effects
    • 5
    • Highly Influenced
    • PDF
    Exploiting the Biosynthetic Potency of Taxol from Fungal Endophytes of Conifers Plants; Genome Mining and Metabolic Manipulation
    • 1
    • PDF

    References

    SHOWING 1-10 OF 63 REFERENCES
    Taxol: A complex diterpenoid natural product with an evolutionarily obscure origin
    • 28
    Taxomyces andreanae: a presumed paclitaxel producer demystified?
    • 60
    • Highly Influential
    Taxol Biosynthesis and Molecular Genetics
    • 323
    An Endophytic Taxol-Producing Fungus from Taxus media, Cladosporium cladosporioides MD2
    • 97
    Taxol-producing [corrected] fungal endophyte, Pestalotiopsis species isolated from Taxus cuspidata.
    • 53
    Taxus spp. needles contain amounts of taxol comparable to the bark of Taxus brevifolia: analysis and isolation.
    • 200
    Cytochrome P450 oxygenases of Taxol biosynthesis
    • 75
    Endophytic fungi: novel sources of anticancer lead molecules
    • Sheela Chandra
    • Biology, Medicine
    • Applied Microbiology and Biotechnology
    • 2012
    • 151
    A new endophytic taxane production fungus from Taxus chinensis
    • 29
    • Highly Influential
    Taxol biosynthesis: Taxane 13α-hydroxylase is a cytochrome P450-dependent monooxygenase
    • 143
    • PDF