Getting to S: CDK functions and targets on the path to cell-cycle commitment

  title={Getting to S: CDK functions and targets on the path to cell-cycle commitment},
  author={Robert P Fisher},
How and when eukaryotic cells make the irrevocable commitment to divide remain central questions in the cell-cycle field. Parallel studies in yeast and mammalian cells seemed to suggest analogous control mechanisms operating during the G1 phase-at Start or the restriction (R) point, respectively-to integrate nutritional and developmental signals and decide between distinct cell fates: cell-cycle arrest or exit versus irreversible commitment to a round of division. Recent work has revealed… CONTINUE READING
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