Getting into the Brain

  title={Getting into the Brain},
  author={Mayur M. Patel and Bhoomika R. Goyal and Shraddha V. Bhadada and Jay S Bhatt and Avani F. Amin},
  journal={CNS Drugs},
Being the most delicate organ of the body, the brain is protected against potentially toxic substances by the blood-brain barrier (BBB), which restricts the entry of most pharmaceuticals into the brain. The developmental process for new drugs for the treatment of CNS disorders has not kept pace with progress in molecular neurosciences because most of the new drugs discovered are unable to cross the BBB. The clinical failure of CNS drug delivery may be attributed largely to a lack of appropriate… 

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The recent advancements achieved in the field from the point of medicinal chemistry view are discussed and how brain drug delivery can be improved in the future are discussed.

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Methods developed for increasing drug delivery to the CNS by circumvention and/or manipulation of the blood-brain barrier have included direct injection into the CSF, administration of prodrugs or chemical delivery systems, or reversible "opening" of the BBB by hyperosmotic agents, pentylenetetrazole, etoposide, DMSO, or other agents.

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This work has shown that the blood-brain barrier provides the platform for CNS drug delivery programs, which should be developed in parallel with traditional CNS drug discovery efforts in the molecular neurosciences.

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The blood-brain barrier (BBB) efficiently restricts penetration of therapeutic agents to the brain from the periphery. Therefore, discovery of new modalities allowing for effective delivery of drugs

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This review intends to detail the recent advances in the field of brain-targeting, rational drug design approach and drug delivery to CNS.

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