Getting into the Brain

@article{Patel2009GettingIT,
  title={Getting into the Brain},
  author={Mayur M. Patel and Bhoomika R. Goyal and Shraddha V. Bhadada and Jay S Bhatt and Avani F. Amin},
  journal={CNS Drugs},
  year={2009},
  volume={23},
  pages={35-58}
}
Being the most delicate organ of the body, the brain is protected against potentially toxic substances by the blood-brain barrier (BBB), which restricts the entry of most pharmaceuticals into the brain. The developmental process for new drugs for the treatment of CNS disorders has not kept pace with progress in molecular neurosciences because most of the new drugs discovered are unable to cross the BBB. The clinical failure of CNS drug delivery may be attributed largely to a lack of appropriate… 

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