Axon guidance in the dopamine system.
- BiologyAdvances in experimental medicine and biology
The current knowledge of the ontogeny of mdDA axon projections in subsystems of the developing rodent central nervous system (CNS) is summarized and the cellular and molecular mechanisms that mediate md DA axon guidance in these CNS regions are discussed.
Axon Guidance in the Dopamine
Current knowledge of the ontogeny ofmdDA axon projections in subsystems of the developingrodent central nervous system (CNS) is summarized and the cellular and molecular mechanisms that mediate md DA axon guidance in these CNS regions are summarized.
The rise and fall of mesodiencephalic dopaminergic neurons: Molecular programming by transcription factors Engrailed 1, Pitx3, and Nkx2.9 during the development of mesodiencephalic neurons
The origin story of the mdDA neuron is investigated in order to understand themdDA system in the healthy, adult brain as well as in the adult brain during pathological conditions and the molecular coding that define the molecular and functional differences between SN and VTA neurons is unraveled.
Midbrain dopaminergic neurons: a review of the molecular circuitry that regulates their development.
- BiologyDevelopmental biology
Genetic control of midbrain dopaminergic neuron development
- Biology, PsychologyWiley interdisciplinary reviews. Developmental biology
This review will discuss insights gained on the signaling network of secreted molecules, cell surface receptors, and transcription factors that regulate specification and differentiation of midbrain dopaminergic progenitors and neurons, from the induction of the ventral midbrain to the migration of dopamine neurons.
Neuronal Subset-Specific Migration and Axonal Wiring Mechanisms in the Developing Midbrain Dopamine System
- BiologyFront. Neuroanat.
This review focuses largely on studies that show differences in these mechanisms between different subsets of mDA neurons and for which in vivo data is available, and is concluded by a section that discusses open questions and provides directions for further research.
Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic Neuron Migration and Dopaminergic Substantia Nigra Development
Specification of dopaminergic subsets involves interplay of En1 and Pitx3
These findings show how two crucial mediators of mdDA neuronal development, En1 and Pitx3, interact in dopaminergic subset specification, the importance of which is exemplified by the specific vulnerability of the SNc found in PD.
Peri-Pubertal Emergence of UNC-5 Homologue Expression by Dopamine Neurons in Rodents
- BiologyPloS one
It is suggested that DCC:UNC5H ratios in DA neurons at critical periods may have important consequences for the organization and function of mesocorticolimbic DA systems.
SHOWING 1-10 OF 118 REFERENCES
Differentiation of the midbrain dopaminergic pathways during mouse development
- BiologyThe Journal of comparative neurology
Dopaminergic (DA) neurons in the substantia nigra (SN) and ventral tegmental area (VTA) of the midbrain project to the dorsolateral caudate/putamen and to the ventromedially located nucleus…
How to make a mesodiencephalic dopaminergic neuron
- Biology, PsychologyNature Reviews Neuroscience
The developmental path of mesodiencephalic dopaminergic neurons is followed with the goal of generating a molecular code that could be exploited in cell-replacement strategies to treat diseases such as Parkinson's disease.
Selective prefrontal cortex inputs to dopamine cells: implications for schizophrenia
- Biology, PsychologyPhysiology & Behavior
Chapter I The organization and circuits of mesencephalic dopaminergic neurons and the distribution of dopamine receptors in the brain
Developmental origin and fate of meso-diencephalic dopamine neurons
- BiologyProgress in Neurobiology
Aberrant trajectory of ascending dopaminergic pathway in mice lacking Nkx2.1
- BiologyExperimental Neurology
Molecular basis for catecholaminergic neuron diversity.
- Biology, PsychologyProceedings of the National Academy of Sciences of the United States of America
Catecholaminergic neurons control diverse cognitive, motor, and endocrine functions and are associated with multiple psychiatric and neurodegenerative disorders. We present global gene-expression…
Distribution of the catecholaminergic neurons in the central nervous system of human embryos and fetuses
- BiologyMicroscopy research and technique
The development and early specification of the dopaminergic neurons expressing calbindin D28K phenotype in the substantia nigra and in the ventral tegmental area are described and a pattern of fiber distribution similar to that described in the adult human brain is described.
Weaver mutation has differential effects on the dopamine-containing innervation of the limbic and nonlimbic striatum
- Biology, PsychologyNature
Evidence is reported that the mesolimbic and nigrostriatal systems are differentially affected in the mutant mouse weaver, and in particular that dopamine is severely depleted in the dorsal striatum of weaver but relatively spared in the ventral striatum.
A Role of Netrin-1 in the Formation of the Subcortical Structure Striatum: Repulsive Action on the Migration of Late-Born Striatal Neurons
- BiologyThe Journal of Neuroscience
The cell tracing study using living brain slices demonstrates that striatal SVZ cells migrate toward and disperse throughout the striatum, in which they differentiate into phenotypes of striatal projection neurons, suggesting that netrin-1 expressed in the striatal VZ serves to guide the large influx of Striatal matrix neurons into the Striatal primordium and is thereby involved in the initial formation of fundamental striatal structures.