Getting connected in the dopamine system

@article{Heuvel2008GettingCI,
  title={Getting connected in the dopamine system},
  author={Dianne M. A. van den Heuvel and R. Jeroen Pasterkamp},
  journal={Progress in Neurobiology},
  year={2008},
  volume={85},
  pages={75-93}
}
Axon guidance in the dopamine system.
TLDR
The current knowledge of the ontogeny of mdDA axon projections in subsystems of the developing rodent central nervous system (CNS) is summarized and the cellular and molecular mechanisms that mediate md DA axon guidance in these CNS regions are discussed.
Axon Guidance in the Dopamine
TLDR
Current knowledge of the ontogeny ofmdDA axon projections in subsystems of the developingrodent central nervous system (CNS) is summarized and the cellular and molecular mechanisms that mediate md DA axon guidance in these CNS regions are summarized.
The rise and fall of mesodiencephalic dopaminergic neurons: Molecular programming by transcription factors Engrailed 1, Pitx3, and Nkx2.9 during the development of mesodiencephalic neurons
TLDR
The origin story of the mdDA neuron is investigated in order to understand themdDA system in the healthy, adult brain as well as in the adult brain during pathological conditions and the molecular coding that define the molecular and functional differences between SN and VTA neurons is unraveled.
Genetic control of midbrain dopaminergic neuron development
  • S. Blaess, S. Ang
  • Biology, Psychology
    Wiley interdisciplinary reviews. Developmental biology
  • 2015
TLDR
This review will discuss insights gained on the signaling network of secreted molecules, cell surface receptors, and transcription factors that regulate specification and differentiation of midbrain dopaminergic progenitors and neurons, from the induction of the ventral midbrain to the migration of dopamine neurons.
Neuronal Subset-Specific Migration and Axonal Wiring Mechanisms in the Developing Midbrain Dopamine System
TLDR
This review focuses largely on studies that show differences in these mechanisms between different subsets of mDA neurons and for which in vivo data is available, and is concluded by a section that discusses open questions and provides directions for further research.
Specification of dopaminergic subsets involves interplay of En1 and Pitx3
TLDR
These findings show how two crucial mediators of mdDA neuronal development, En1 and Pitx3, interact in dopaminergic subset specification, the importance of which is exemplified by the specific vulnerability of the SNc found in PD.
Peri-Pubertal Emergence of UNC-5 Homologue Expression by Dopamine Neurons in Rodents
TLDR
It is suggested that DCC:UNC5H ratios in DA neurons at critical periods may have important consequences for the organization and function of mesocorticolimbic DA systems.
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