Getting connected in the dopamine system

@article{Heuvel2008GettingCI,
  title={Getting connected in the dopamine system},
  author={Dianne M. A. van den Heuvel and R. Jeroen Pasterkamp},
  journal={Progress in Neurobiology},
  year={2008},
  volume={85},
  pages={75-93}
}
View on Elsevier
doi.org
181 Citations
Highly Influential Citations
8
Background Citations
66
Methods Citations
1
Results Citations
1

181 Citations

Citation Type

Citation Type

Axon guidance in the dopamine system.
TLDR
The current knowledge of the ontogeny of mdDA axon projections in subsystems of the developing rodent central nervous system (CNS) is summarized and the cellular and molecular mechanisms that mediate md DA axon guidance in these CNS regions are discussed.
Axon Guidance in the Dopamine
TLDR
Current knowledge of the ontogeny ofmdDA axon projections in subsystems of the developingrodent central nervous system (CNS) is summarized and the cellular and molecular mechanisms that mediate md DA axon guidance in these CNS regions are summarized.
The rise and fall of mesodiencephalic dopaminergic neurons: Molecular programming by transcription factors Engrailed 1, Pitx3, and Nkx2.9 during the development of mesodiencephalic neurons
TLDR
The origin story of the mdDA neuron is investigated in order to understand themdDA system in the healthy, adult brain as well as in the adult brain during pathological conditions and the molecular coding that define the molecular and functional differences between SN and VTA neurons is unraveled.
The Generation of Midbrain Dopaminergic Neurons
Midbrain dopaminergic neurons: a review of the molecular circuitry that regulates their development.
Genetic control of midbrain dopaminergic neuron development
  • S. Blaess, S. Ang
  • Biology, Psychology
    Wiley interdisciplinary reviews. Developmental biology
  • 2015
TLDR
This review will discuss insights gained on the signaling network of secreted molecules, cell surface receptors, and transcription factors that regulate specification and differentiation of midbrain dopaminergic progenitors and neurons, from the induction of the ventral midbrain to the migration of dopamine neurons.
Neuronal Subset-Specific Migration and Axonal Wiring Mechanisms in the Developing Midbrain Dopamine System
TLDR
This review focuses largely on studies that show differences in these mechanisms between different subsets of mDA neurons and for which in vivo data is available, and is concluded by a section that discusses open questions and provides directions for further research.
Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic Neuron Migration and Dopaminergic Substantia Nigra Development
Specification of dopaminergic subsets involves interplay of En1 and Pitx3
TLDR
These findings show how two crucial mediators of mdDA neuronal development, En1 and Pitx3, interact in dopaminergic subset specification, the importance of which is exemplified by the specific vulnerability of the SNc found in PD.
Specification of dopaminergic subsets involves interplay of En1 and Pitx3
TLDR
These findings show how two crucial mediators of mdDA neuronal development, En1 and Pitx3, interact in dopaminergic subset specification, the importance of which is exemplified by the specific vulnerability of the SNc found in PD.
...
...

References

SHOWING 1-10 OF 118 REFERENCES
Differentiation of the midbrain dopaminergic pathways during mouse development
Dopaminergic (DA) neurons in the substantia nigra (SN) and ventral tegmental area (VTA) of the midbrain project to the dorsolateral caudate/putamen and to the ventromedially located nucleus…
How to make a mesodiencephalic dopaminergic neuron
TLDR
The developmental path of mesodiencephalic dopaminergic neurons is followed with the goal of generating a molecular code that could be exploited in cell-replacement strategies to treat diseases such as Parkinson's disease.
Selective prefrontal cortex inputs to dopamine cells: implications for schizophrenia
Chapter I The organization and circuits of mesencephalic dopaminergic neurons and the distribution of dopamine receptors in the brain
Developmental origin and fate of meso-diencephalic dopamine neurons
Aberrant trajectory of ascending dopaminergic pathway in mice lacking Nkx2.1
Molecular basis for catecholaminergic neuron diversity.
Catecholaminergic neurons control diverse cognitive, motor, and endocrine functions and are associated with multiple psychiatric and neurodegenerative disorders. We present global gene-expression…
Distribution of the catecholaminergic neurons in the central nervous system of human embryos and fetuses
  • C. Verney
  • Biology
    Microscopy research and technique
  • 1999
TLDR
The development and early specification of the dopaminergic neurons expressing calbindin D28K phenotype in the substantia nigra and in the ventral tegmental area are described and a pattern of fiber distribution similar to that described in the adult human brain is described.
Weaver mutation has differential effects on the dopamine-containing innervation of the limbic and nonlimbic striatum
TLDR
Evidence is reported that the mesolimbic and nigrostriatal systems are differentially affected in the mutant mouse weaver, and in particular that dopamine is severely depleted in the dorsal striatum of weaver but relatively spared in the ventral striatum.
A Role of Netrin-1 in the Formation of the Subcortical Structure Striatum: Repulsive Action on the Migration of Late-Born Striatal Neurons
TLDR
The cell tracing study using living brain slices demonstrates that striatal SVZ cells migrate toward and disperse throughout the striatum, in which they differentiate into phenotypes of striatal projection neurons, suggesting that netrin-1 expressed in the striatal VZ serves to guide the large influx of Striatal matrix neurons into the Striatal primordium and is thereby involved in the initial formation of fundamental striatal structures.
...
...