Getting Out of a Sticky Situation: Targeting the Myofibroblast in Scleroderma

@inproceedings{Leask2012GettingOO,
  title={Getting Out of a Sticky Situation: Targeting the Myofibroblast in Scleroderma},
  author={Andrew Leask},
  booktitle={The open rheumatology journal},
  year={2012}
}
There is no treatment for the fibrosis observed in scleroderma (systemic sclerosis, SSc). Although genome-wide expression profiling has suggested that differences in gene expression patters between non-lesional and lesional skin are minimal, phenotypically these areas of tissue are quite different. In fact, lesional areas of scleroderma patients can be distinguished by the presence of a differentiated form of fibroblast, termed the myofibroblast. This cell type expresses the highly contractile… CONTINUE READING

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