Getting Out of a Sticky Situation: Targeting the Myofibroblast in Scleroderma

  title={Getting Out of a Sticky Situation: Targeting the Myofibroblast in Scleroderma},
  author={A. Leask},
  journal={The Open Rheumatology Journal},
  pages={163 - 169}
  • A. Leask
  • Published 2012
  • Medicine
  • The Open Rheumatology Journal
  • There is no treatment for the fibrosis observed in scleroderma (systemic sclerosis, SSc). Although genome-wide expression profiling has suggested that differences in gene expression patters between non-lesional and lesional skin are minimal, phenotypically these areas of tissue are quite different. In fact, lesional areas of scleroderma patients can be distinguished by the presence of a differentiated form of fibroblast, termed the myofibroblast. This cell type expresses the highly contractile… CONTINUE READING
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