Getting Out of a Sticky Situation: Targeting the Myofibroblast in Scleroderma

  title={Getting Out of a Sticky Situation: Targeting the Myofibroblast in Scleroderma},
  author={Andrew Leask},
  booktitle={The open rheumatology journal},
There is no treatment for the fibrosis observed in scleroderma (systemic sclerosis, SSc). Although genome-wide expression profiling has suggested that differences in gene expression patters between non-lesional and lesional skin are minimal, phenotypically these areas of tissue are quite different. In fact, lesional areas of scleroderma patients can be distinguished by the presence of a differentiated form of fibroblast, termed the myofibroblast. This cell type expresses the highly contractile… CONTINUE READING

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CCN2 is necessary for adhesive responses to TGFß1 in embryonic fibroblasts

  • X Shi-wen, L Stanton, L Kennedy
  • J Biol Chem
  • 2006
Highly Influential
14 Excerpts

Constitutive ALK5-indepenent JNK activation contributes to endothelin-1 overexpression in pulmonary fibrosis

  • X Shi-wen, F Rodrigues-Pascual, S Lamas
  • Mol Cell Biol
  • 2006
Highly Influential
5 Excerpts

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