Getting Lost: Directed Attention and Executive Functions in Early Alzheimer’s Disease Patients
@article{Chiu2004GettingLD, title={Getting Lost: Directed Attention and Executive Functions in Early Alzheimer’s Disease Patients}, author={Yi-Chen Chiu and Donna Algase and Ann F. Whall and Jersey Liang and Hsiu-Chih Liu and Ker‐Neng Lin and Pei-Ning Wang}, journal={Dementia and Geriatric Cognitive Disorders}, year={2004}, volume={17}, pages={174 - 180} }
This study explores the link between directed attention (DA) and getting lost behavior (GLB) in early Alzheimer’s disease (AD) using a cross-sectional design with 3 groups. Based on their dementia levels, 116 community-dwelling participants were recruited from a teaching hospital in Taiwan and classified as the non-demented control, questionably demented, and mild AD groups. Statistical analyses include Pearson correlations, one-way ANOVA, and multiple regressions. Attentional impairments…
84 Citations
Getting Lost Behavior in Patients with Mild Alzheimer’s Disease: A Cognitive and Anatomical Model
- Psychology, BiologyFront. Med.
- 2017
Cognitively, a top-down modulation deficit may driveGLB in both healthy elderly and patients with mild AD, and anatomical substrates of GLB in mild AD may not follow the typical top- down modulation mechanisms often reported in the healthy aging population.
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This finding suggested that in addition to episodic memory disturbance, frontal lobe dysfunctions might lead patients with AD to develop aberrant motor behavior.
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This study showed that AD patients with wandering have disproportionately cognitive deficit suggesting frontal and right parietal dysfunctions, and wanderings are related with specific BPSD.
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The results showed that the RMRT has a sound reliability and discriminative validity for the diagnosis of AD, and its clinical utility to predict the GL risk is supported.
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It is suggested that before the occurrence of GL, the caregivers of PwAD should refer to the results of cognitive assessment and navigation ability evaluation to enhance the orientation and attention of the Pwad.
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A computational approach is presented to facilitate brain region-specific analysis of genes and biological processes involved in the memory process in AD and can be used to bridge the genotype–phenotype gap and allow for new therapeutic hypotheses.
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