• Corpus ID: 4238125

Getting High on the Endocannabinoid System

@article{Alger2013GettingHO,
  title={Getting High on the Endocannabinoid System},
  author={Bradley E. Alger},
  journal={Cerebrum: the Dana Forum on Brain Science},
  year={2013},
  volume={2013}
}
  • B. Alger
  • Published 1 November 2013
  • Medicine, Biology
  • Cerebrum: the Dana Forum on Brain Science
Editor’s Note: The endogenous cannabinoid system—named for the plant that led to its discovery—is one of the most important physiologic systems involved in establishing and maintaining human health. Endocannabinoids and their receptors are found throughout the body: in the brain, organs, connective tissues, glands, and immune cells. With its complex actions in our immune system, nervous system, and virtually all of the body’s organs, the endocannabinoids are literally a bridge between body and… 
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References

SHOWING 1-10 OF 39 REFERENCES

Endocannabinoid signaling in microglial cells

Molecular characterization of a peripheral receptor for cannabinoids

The cloning of a receptor for cannabinoids is reported that is not expressed in the brain but rather in macrophages in the marginal zone of spleen, which helps clarify the non-psychoactive effects of cannabinoids.

Endocannabinoid system and mood disorders: priming a target for new therapies.

Anandamide hydrolysis: a new target for anti-anxiety drugs?

Role of endogenous cannabinoids in synaptic signaling.

The synthetic pathways of endocannabinoids are discussed, along with the putative mechanisms of their release, uptake, and degradation, and the fine-grain anatomical distribution of the neuronal cannabinoid receptor CB1 is described in most brain areas, emphasizing its general presynaptic localization and role in controlling neurotransmitter release.

Isolation and structure of a brain constituent that binds to the cannabinoid receptor.

Arachidonylethanolamide, an arachidonic acid derivative in porcine brain, was identified in a screen for endogenous ligands for the cannabinoid receptor. The structure of this compound, which has…

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

The cloning and expression of a complementary DNA that encodes a G protein-coupled receptor that is involved in cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana are suggested.

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors.

Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

Individual endocannabinoids generate distinct analgesic profiles that are either sustained or transitory and associated with agonism and functional antagonism of the brain cannabinoid system, respectively.

Metabotropic Glutamate Receptors Drive the Endocannabinoid System in Hippocampus

It is concluded that group I mGluR-induced enhancement of DSI, and suppression of IPSCs, is actually mediated by endocannabinoids, which opens up new approaches to the investigation of cannabinoid actions in the brain.