• Corpus ID: 4238125

Getting High on the Endocannabinoid System

  title={Getting High on the Endocannabinoid System},
  author={Bradley E. Alger},
  journal={Cerebrum: the Dana Forum on Brain Science},
  • B. Alger
  • Published 1 November 2013
  • Medicine, Biology
  • Cerebrum: the Dana Forum on Brain Science
Editor’s Note: The endogenous cannabinoid system—named for the plant that led to its discovery—is one of the most important physiologic systems involved in establishing and maintaining human health. Endocannabinoids and their receptors are found throughout the body: in the brain, organs, connective tissues, glands, and immune cells. With its complex actions in our immune system, nervous system, and virtually all of the body’s organs, the endocannabinoids are literally a bridge between body and… 

The Endocannabinoid System and Its Therapeutic Potential

The widespread neuromodulatory role of the endocannabinoid system has shown promise in acute and chronic pain regulation, but the presence of cannabinoid receptors on both excitatory and inhibitory neurons demonstrates a need for further research that is more directed towards specific receptors.

The Endocannabinoid System, Our Universal Regulator

The Endocannabinoid System, The authors' Universal Regulator is one of the most understudied systems in the human body and is directly involved with various roles in apoptosis, neurotransmitter levels, and homeostasis.

New Insights Into Peptide Cannabinoids: Structure, Biosynthesis and Signaling

The discussion on the current knowledge of the pharmacological effects, the biosynthesis of the peptide cannabinoids and the new insights on the activation and modulation of cannabinoid receptors by these peptides are focused on.

A Review of the Relationship between the Endocannabinoid System and the Reduction of Depression and Anxiety

Although current research into the prospective use of endocannabinoid receptor ligands as antidepressants is limited, this review details the field’s most salient advancements toward potential clinical applications.

Potential Therapeutic Targets of the Endocannabinoid System in Common Neurodegenerative Disorders and Organic Acidemias

The cannabinoid chemistry is currently being addressed in preclinical approaches as a viable therapeutic alternative for the management of a wide range of signs, symptoms, and some biochemical hall...

Exploring the Utility of Hair Endocannabinoids for Monitoring Homeostasis in Bonobos

It is concluded that the EC system potentially provides novel tools to assess well-being, health status, and metabolic stress—not only in the hair of humans but also in that of domestic and wild animals.

Measuring Disturbance of the Endocannabinoid System in Psychosis: A Systematic Review and Meta-analysis.

Testing clinically relevant markers of the ECS in the blood and CSF of people with psychotic illness appears possible, and these markers provide useful biomarkers for the psychotic disorder; however, not all studies accounted for important variables, such as cannabis use.

Role of endocannabinoids in the progression of diabetic retinopathy

This review aims at unveiling every aspect of association of the endocannabinoid system and its interactions with various physiological and pathological pathways to induce disease progression and might provide a therapeutic alternative target to combat and restrict its progression amongst diabetic patients.

Synthetic Pot: Not Your Grandfather's Marijuana.



Endocannabinoid signaling in microglial cells

Molecular characterization of a peripheral receptor for cannabinoids

The cloning of a receptor for cannabinoids is reported that is not expressed in the brain but rather in macrophages in the marginal zone of spleen, which helps clarify the non-psychoactive effects of cannabinoids.

Endocannabinoid system and mood disorders: priming a target for new therapies.

Anandamide hydrolysis: a new target for anti-anxiety drugs?

Role of endogenous cannabinoids in synaptic signaling.

The synthetic pathways of endocannabinoids are discussed, along with the putative mechanisms of their release, uptake, and degradation, and the fine-grain anatomical distribution of the neuronal cannabinoid receptor CB1 is described in most brain areas, emphasizing its general presynaptic localization and role in controlling neurotransmitter release.

Isolation and structure of a brain constituent that binds to the cannabinoid receptor.

Arachidonylethanolamide, an arachidonic acid derivative in porcine brain, was identified in a screen for endogenous ligands for the cannabinoid receptor. The structure of this compound, which has

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

The cloning and expression of a complementary DNA that encodes a G protein-coupled receptor that is involved in cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana are suggested.

Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

Individual endocannabinoids generate distinct analgesic profiles that are either sustained or transitory and associated with agonism and functional antagonism of the brain cannabinoid system, respectively.

Metabotropic Glutamate Receptors Drive the Endocannabinoid System in Hippocampus

It is concluded that group I mGluR-induced enhancement of DSI, and suppression of IPSCs, is actually mediated by endocannabinoids, which opens up new approaches to the investigation of cannabinoid actions in the brain.