Corpus ID: 4238125

Getting High on the Endocannabinoid System

@article{Alger2013GettingHO,
  title={Getting High on the Endocannabinoid System},
  author={Bradley E Alger},
  journal={Cerebrum: the Dana Forum on Brain Science},
  year={2013},
  volume={2013}
}
  • B. Alger
  • Published 1 November 2013
  • Medicine, Chemistry
  • Cerebrum: the Dana Forum on Brain Science
Editor’s Note: The endogenous cannabinoid system—named for the plant that led to its discovery—is one of the most important physiologic systems involved in establishing and maintaining human health. Endocannabinoids and their receptors are found throughout the body: in the brain, organs, connective tissues, glands, and immune cells. With its complex actions in our immune system, nervous system, and virtually all of the body’s organs, the endocannabinoids are literally a bridge between body and… Expand
The Endocannabinoid System and Its Therapeutic Potential
The endocannabinoid system is a popular topic in regards to creating therapeutics for a multitude of nervous system disorders. The endocannabinoid system, a naturally occurring system in the humanExpand
The Endocannabinoid System, Our Universal Regulator
TLDR
The Endocannabinoid System, The authors' Universal Regulator is one of the most understudied systems in the human body and is directly involved with various roles in apoptosis, neurotransmitter levels, and homeostasis. Expand
Diverse role of endocannabinoid system in mammalian male reproduction.
TLDR
The role of ECS inmale reproductive system is emerging and the presence of a complete enzymatic machinery to synthesize and metabolize eCBs has been demonstrated in male reproductive tract, an attempt to provide an insight into the significant role of endocannabinoids in male reproduction. Expand
New Insights Into Peptide Cannabinoids: Structure, Biosynthesis and Signaling
TLDR
The discussion on the current knowledge of the pharmacological effects, the biosynthesis of the peptide cannabinoids and the new insights on the activation and modulation of cannabinoid receptors by these peptides are focused on. Expand
A Review of the Relationship between the Endocannabinoid System and the Reduction of Depression and Anxiety
The growing acceptance of cannabis use for medical and recreational purposes across the world has sparked interest in evaluation of the therapeutic potential of the drug. While the beneficial effectsExpand
Exploring the Utility of Hair Endocannabinoids for Monitoring Homeostasis in Bonobos
TLDR
It is concluded that the EC system potentially provides novel tools to assess well-being, health status, and metabolic stress—not only in the hair of humans but also in that of domestic and wild animals. Expand
Measuring Disturbance of the Endocannabinoid System in Psychosis: A Systematic Review and Meta-analysis.
TLDR
Testing clinically relevant markers of the ECS in the blood and CSF of people with psychotic illness appears possible, and these markers provide useful biomarkers for the psychotic disorder; however, not all studies accounted for important variables, such as cannabis use. Expand
Role of endocannabinoids in the progression of diabetic retinopathy
TLDR
This review aims at unveiling every aspect of association of the endocannabinoid system and its interactions with various physiological and pathological pathways to induce disease progression and might provide a therapeutic alternative target to combat and restrict its progression amongst diabetic patients. Expand
Synthetic Pot: Not Your Grandfather's Marijuana.
TLDR
Synthetic cannabinoids are a highly structural diverse group of compounds, easily synthesized, which produce very dangerous adverse effects occurring by, as of yet, unknown mechanisms. Expand
Application of medical cannabis in unstable angina and coronary artery disease
TLDR
This case uniquely highlights MC in possibly reducing the character, quality, and frequency of UA, whereas concordantly improving functional cardiac capacity in a patient with CAD. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 39 REFERENCES
Endocannabinoid signaling in microglial cells
  • N. Stella
  • Medicine, Biology
  • Neuropharmacology
  • 2009
TLDR
It is argued that compounds selectively targeting the eCBSS expressed by microglia constitute valuable therapeutics to manage acute and chronic neuroinflammation, without inducing the psychotropic effects and underlying addictive properties commonly associated with THC. Expand
Molecular characterization of a peripheral receptor for cannabinoids
TLDR
The cloning of a receptor for cannabinoids is reported that is not expressed in the brain but rather in macrophages in the marginal zone of spleen, which helps clarify the non-psychoactive effects of cannabinoids. Expand
Endocannabinoid system and mood disorders: priming a target for new therapies.
TLDR
The state of the art of the possible therapeutic use of endocannabinoid deactivation inhibitors and phytocannabinoids in mood disorders is discussed in this review article. Expand
Anandamide hydrolysis: a new target for anti-anxiety drugs?
TLDR
Pharmacological blockade of the enzyme fatty acid amide hydrolase (FAAH), which is responsible for intracellular anandamide degradation, produces anxiolytic-like effects in rats without causing the wide spectrum of behavioral responses typical of direct-acting cannabinoid agonists. Expand
Role of endogenous cannabinoids in synaptic signaling.
TLDR
The synthetic pathways of endocannabinoids are discussed, along with the putative mechanisms of their release, uptake, and degradation, and the fine-grain anatomical distribution of the neuronal cannabinoid receptor CB1 is described in most brain areas, emphasizing its general presynaptic localization and role in controlling neurotransmitter release. Expand
Isolation and structure of a brain constituent that binds to the cannabinoid receptor.
Arachidonylethanolamide, an arachidonic acid derivative in porcine brain, was identified in a screen for endogenous ligands for the cannabinoid receptor. The structure of this compound, which hasExpand
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
TLDR
The cloning and expression of a complementary DNA that encodes a G protein-coupled receptor that is involved in cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana are suggested. Expand
Anandamide and vanilloid TRPV1 receptors
  • R. Ross
  • Chemistry, Medicine
  • British journal of pharmacology
  • 2003
TLDR
The activation of TRPV1 receptors by an andamide has potential implications in the treatment of inflammatory, respiratory and cardiovascular disorders and the relative importance of anandamide as a physiological and/or pathophysiological TRPv1 receptor agonist in comparison to other potential candidates has yet to be revealed. Expand
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors.
TLDR
Upon intravenous administration to mice, 2-Ara-Gl caused the typical tetrad of effects produced by THC: antinociception, immobility, reduction of spontaneous activity, and lowering of the rectal temperature. Expand
Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system
TLDR
Individual endocannabinoids generate distinct analgesic profiles that are either sustained or transitory and associated with agonism and functional antagonism of the brain cannabinoid system, respectively. Expand
...
1
2
3
4
...