Gettin' down with ubiquitin: turning off cell-surface receptors, transporters and channels.

@article{Hicke1999GettinDW,
  title={Gettin' down with ubiquitin: turning off cell-surface receptors, transporters and channels.},
  author={Linda Hicke},
  journal={Trends in cell biology},
  year={1999},
  volume={9 3},
  pages={107-12}
}
G-protein-coupled receptors and transporters in Saccharomyces cerevisiae are modified with ubiquitin in response to ligand biding. In most cases, the proteasome does not recognize these ubiquitinated proteins. Instead, ubiquitination serves to trigger internalization and degradation of plasma membrane proteins in the lysosome-like vacuole. A number of mammalian receptors and at least one ion channel undergo ubiquitination at the plasma membrane, and this modification is required for their… CONTINUE READING

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