Get a ligand, get a life: integrins, signaling and cell survival.

@article{Stupack2002GetAL,
  title={Get a ligand, get a life: integrins, signaling and cell survival.},
  author={Dwayne G Stupack and David A. Cheresh},
  journal={Journal of cell science},
  year={2002},
  volume={115 Pt 19},
  pages={
          3729-38
        }
}
Programmed cell death is crucial for the development and maintenance of multicellular organisms. The decision to live, or to die, depends, at the cellular level, upon the cell's interaction with extracellular cues that trigger cell signaling pathways promoting survival or death. The extracellular matrix (ECM) influences the execution of the apoptotic program through the actions of adhesion receptors. Among these, integrins initiate a variety of downstream signaling events in response to ECM… CONTINUE READING

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