Gestrinone (R2323) Binding to Steroid Receptors in Human Uterine Endometrial Cytosol

  title={Gestrinone (R2323) Binding to Steroid Receptors in Human Uterine Endometrial Cytosol},
  author={T. Tamaya and J. Fujimoto and Y. Watanabe and K. Arahori and H. Okada},
  journal={Acta Obstetricia et Gynecologica Scandinavica},
  • T. Tamaya, J. Fujimoto, +2 authors H. Okada
  • Published 1986
  • Medicine
  • Acta Obstetricia et Gynecologica Scandinavica
  • To understand the mechanism of biological action of gestrinone (R2323), which has a therapeutic effect against endometriosis, the binding of gestrinone to numerous classes of intracellular steroid binding proteins was studied in the human uterine endometrium. Gestrinone bound to endometrial receptors for estrogen, progesterone and androgen, but seemed not to bind to endometrial intracellular corticosteroid‐binding globulin and sex hormone‐binding globulin. Gestrinone occupies all specific… CONTINUE READING
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