Gestational zinc deficiency affects the regulation of transcription factors AP-1, NF-κB and NFAT in fetal brain.

@article{Aimo2010GestationalZD,
  title={Gestational zinc deficiency affects the regulation of transcription factors AP-1, NF-κB and NFAT in fetal brain.},
  author={Lucila Aimo and Gerardo G Mackenzie and Alison H Keenan and Patricia I. Oteiza},
  journal={The Journal of nutritional biochemistry},
  year={2010},
  volume={21 11},
  pages={
          1069-75
        }
}
Transcription factors AP-1, nuclear factor κB (NF-κB) and NFAT are central to brain development by regulating the expression of genes that modulate cell proliferation, differentiation, apoptosis and synaptic plasticity. This work investigated the consequences of feeding zinc-deficient and marginal zinc diets to rat dams during gestation on the modulation of AP-1, NF-κB and NFAT in fetal brain. Sprague-Dawley rats were fed from gestation day (GD) 0 a control diet ad libitum (25 μg zinc/g diet, C… CONTINUE READING

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