Gestational vitamin B deficiency leads to homocysteine-associated brain apoptosis and alters neurobehavioral development in rats.

@article{Blaise2007GestationalVB,
  title={Gestational vitamin B deficiency leads to homocysteine-associated brain apoptosis and alters neurobehavioral development in rats.},
  author={S{\'e}bastien Blaise and Emmanuelle N{\'e}d{\'e}lec and Henri Schroeder and J Alberto and Carine Bossenmeyer-Pouri{\'e} and Jean-Louis Gu{\'e}ant and Jean-Luc Daval},
  journal={The American journal of pathology},
  year={2007},
  volume={170 2},
  pages={667-79}
}
Hyperhomocysteinemia has been identified as a risk factor for neurological disorders. To study the influence of early deficiency in nutritional determinants of hyperhomocysteinemia on the developing rat brain, dams were fed a standard diet or a diet lacking methyl groups during gestation and lactation. Homocysteinemia progressively increased in the offspring of the deficient group and at 21 days reached 13.3+/-3.7 micromol/L versus 6.8+/-0.3 micromol/L in controls. Homocysteine accumulated in… CONTINUE READING