Gestational trophoblastic diseases: 1. Pathophysiology of hyperglycosylated hCG.

  title={Gestational trophoblastic diseases: 1. Pathophysiology of hyperglycosylated hCG.},
  author={Laurence A. Cole and Donghai Dai and Stephen Andrew Butler and Kimberly K. Leslie and Ernest I. Kohorn},
  journal={Gynecologic oncology},
  volume={102 2},
OBJECTIVE Hyperglycosylated hCG (hCG-H) is a glycosylation variant of hCG produced by cytotrophoblast cells at implantation of pregnancy and in choriocarcinoma. We investigated the biological function of hCG-H in invasion in vitro and in vivo and the use of hCG-H antibodies in blocking tumorigenesis and cancer growth in vivo. METHODS AND RESULTS hCG-H accounts for 43% to 100% of total hCG immunoreactivity in the culture fluid of choriocarcinoma cell lines and 100% in primary cultures of… CONTINUE READING


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