Gestational-neonatal iron deficiency suppresses and iron treatment reactivates IGF signaling in developing rat hippocampus.

@article{Tran2012GestationalneonatalID,
  title={Gestational-neonatal iron deficiency suppresses and iron treatment reactivates IGF signaling in developing rat hippocampus.},
  author={Phu V. Tran and Stephanie J. B. Fretham and Jane D. Wobken and Bradley S. Miller and Michael K. Georgieff},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2012},
  volume={302 3},
  pages={E316-24}
}
Gestational-neonatal iron deficiency, a common micronutrient deficiency affecting the offspring of more than 30% of pregnancies worldwide, leads to long-term cognitive and behavioral abnormalities. Preclinical models of gestational-neonatal iron deficiency result in reduced energy metabolism and expression of genes critical for neuronal plasticity and cognitive function, which are associated with a smaller hippocampal volume and abnormal neuronal dendrite growth. Because insulin-like growth… CONTINUE READING
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