Gestational immune activation and Tsc2 haploinsufficiency cooperate to disrupt fetal survival and may perturb social behavior in adult mice

@article{Ehninger2012GestationalIA,
  title={Gestational immune activation and Tsc2 haploinsufficiency cooperate to disrupt fetal survival and may perturb social behavior in adult mice},
  author={Dan Ehninger and Yaeko Sano and P J de Vries and Kira A. Dies and Dafne Franz and Daniel H. Geschwind and Manjyot Kaur and Y Lee and Wenxin Li and Jennifer K. Lowe and Jo Anne Nakagawa and Mustafa Sahin and K Smith and Vicky H. Whittemore and Alcino J. Silva},
  journal={Molecular Psychiatry},
  year={2012},
  volume={17},
  pages={62-70}
}
Approximately 40–50% of individuals affected by tuberous sclerosis (TSC) develop autism spectrum disorders (ASDs). One possible explanation for this partial penetrance is an interaction between TSC gene mutations and other risk factors such as gestational immune activation. In this study, we report the interactive effects of these two ASD risk factors in a mouse model of TSC. Combined, but not single, exposure had adverse effects on intrauterine survival. Additionally, provisional results… CONTINUE READING
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