Gestational exposure to antidepressants and the risk of spontaneous abortion: a review.

@article{Broy2010GestationalET,
  title={Gestational exposure to antidepressants and the risk of spontaneous abortion: a review.},
  author={Perrine Broy and Anick B{\'e}rard},
  journal={Current drug delivery},
  year={2010},
  volume={7 1},
  pages={
          76-92
        }
}
BACKGROUND Although the relationship between antidepressant use during pregnancy and its adverse effects has been widely investigated, very few studies have evaluated the impact of antidepressant use during pregnancy on the risk of spontaneous abortion. We present an overview of the evidence relating to the association between antidepressant use during gestation and the risk of spontaneous abortion. METHODS We systematically searched PubMed and the reference lists of all relevant articles… 

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References

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Antidepressant Use during Pregnancy and the Rates of Spontaneous Abortions: A Meta-Analysis
TLDR
Maternal exposure to antidepressants may be associated with increased risk for SA; however, depression itself cannot be ruled out.
Rates of spontaneous and therapeutic abortions following use of antidepressants in pregnancy: results from a large prospective database.
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TLDR
To identify risk factors associated with treatment of major depression during pregnancy to help physicians develop treatment plans that optimize clinical care, prospective studies published since 1993 were selected.
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TLDR
The results suggest that the use of venlafaxine during pregnancy does not increase the rates of major malformations above the baseline rate of 1%-3%.
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TLDR
This study suggests a possible association between cardiovascular anomalies and first-trimester exposure to fluoxetine in mothers using selective serotonin reuptake inhibitors.
Exposure to mirtazapine during pregnancy: a prospective, comparative study of birth outcomes.
TLDR
Mirtazapine does not appear to increase the baseline rate of major malformations in newborns when used by pregnant women, but the higher number of spontaneous abortions in the antidepressant groups confirms the higher rates of spontaneous pregnancies in pregnant women taking antidepressant medications found in previous studies.
Use of selective serotonin-reuptake inhibitors in pregnancy and the risk of birth defects
TLDR
This study failed to establish any association between the maternal use of SSRIs during early pregnancy and an elevated risk of congenital heart defects-or of several other classes of birth defects.
First trimester exposure to paroxetine and risk of cardiac malformations in infants: the importance of dosage.
TLDR
Gestational exposure to paroxetine is associated with major congenital malformations and major cardiac malformation for only first trimester exposure above 25 mg/day, and the dose-response relationship was observed.
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