Gestational diabetes exacerbates maternal immune activation effects in the developing brain

@article{Money2018GestationalDE,
  title={Gestational diabetes exacerbates maternal immune activation effects in the developing brain},
  author={Kelli M. Money and Theresa L Barke and Ana Serezani and Maureen A. Gannon and Krassimira A. Garbett and David M Aronoff and K{\'a}roly Mirnics},
  journal={Molecular Psychiatry},
  year={2018},
  volume={23},
  pages={1920-1928}
}
Maternal inflammation and diabetes increase the risk for psychiatric disorders in offspring. We hypothesized that these co-occurring risk factors may potentiate each other. To test this, we maternally exposed developing mice in utero to gestational diabetes mellitus (GDM) and/or maternal immune activation (MIA). Fetal mouse brains were exposed to either vehicle, GDM, MIA or GDM+MIA. At gestational day (GD) 12.5, GDM produced a hyperglycemic, hyperleptinemic maternal state, whereas MIA produced… CONTINUE READING
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