Gestational and postpartum corticosterone exposure to the dam affects behavioral and endocrine outcome of the offspring in a sexually-dimorphic manner.

@article{Brummelte2012GestationalAP,
  title={Gestational and postpartum corticosterone exposure to the dam affects behavioral and endocrine outcome of the offspring in a sexually-dimorphic manner.},
  author={Susanne Brummelte and Stephanie E. Lieblich and Liisa A M Galea},
  journal={Neuropharmacology},
  year={2012},
  volume={62 1},
  pages={406-18}
}
Exposure to high levels of glucocorticoids in utero and during the postpartum period has a detrimental effect on brain development. We created an animal model of postpartum stress/depression based on administering high levels of corticosterone (CORT) to the dams during the postpartum period which caused behavioral changes and reduced hippocampal cell proliferation in the offspring. As the consequences of early exposure to glucocorticoids may depend on the dose and the developmental stage of the… CONTINUE READING