Gestational Methylazoxymethanol Acetate Administration Alters Proteomic and Metabolomic Markers of Hippocampal Glutamatergic Transmission

@article{Lodge2012GestationalMA,
  title={Gestational Methylazoxymethanol Acetate Administration Alters Proteomic and Metabolomic Markers of Hippocampal Glutamatergic Transmission},
  author={Daniel J Lodge and Anthony A. Grace},
  journal={Neuropsychopharmacology},
  year={2012},
  volume={37},
  pages={319-320}
}
Gestational methylazoxymethanol acetate (MAM) administration produces deficits consistent with those observed in schizophrenia patients, including anatomical changes, behavioral deficits, and altered neuronal information processing (for review see Lodge and Grace (2009b)). Behaviorally, MAM-treated rats display deficits in prepulse inhibition of startle, latent inhibition, working memory, social interaction, and an enhanced response to psychomotor stimulants. The mechanisms underlying these… CONTINUE READING

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