Gestational Choline Deficiency Causes Global and Igf2 Gene DNA Hypermethylation by Up-regulation of Dnmt1 Expression*

@article{Kovacheva2007GestationalCD,
  title={Gestational Choline Deficiency Causes Global and Igf2 Gene DNA Hypermethylation by Up-regulation of Dnmt1 Expression*},
  author={V. Kovacheva and Tiffany J. Mellott and J. Davison and N. Wagner and I. L{\'o}pez-Coviella and A. Schnitzler and J. Blusztajn},
  journal={Journal of Biological Chemistry},
  year={2007},
  volume={282},
  pages={31777 - 31788}
}
During gestation there is a high demand for the essential nutrient choline. Adult rats supplemented with choline during embryonic days (E) 11-17 have improved memory performance and do not exhibit age-related memory decline, whereas prenatally choline-deficient animals have memory deficits. Choline, via betaine, provides methyl groups for the production of S-adenosylmethionine, a substrate of DNA methyltransferases (DNMTs). We describe an apparently adaptive epigenomic response to varied… Expand

Paper Mentions

Interventional Clinical Trial
Gestational diabetes mellitus (GDM), characterized by maternal high blood sugar, affects up to 15% of pregnancies worldwide. GDM doubles the risk of fetal growth (i.e. macrosomia, large… Expand
ConditionsGestational Diabetes
InterventionDietary Supplement
Choline deficiency alters global histone methylation and epigenetic marking at the Rel site of the calbindin 1 gene
Choline nutrition programs brain development via DNA and histone methylation.
Choline, Other Methyl-Donors and Epigenetics
Raising gestational choline intake alters gene expression in DMBA‐evoked mammary tumors and prolongs survival
  • V. Kovacheva, J. Davison, +4 authors J. Blusztajn
  • Medicine, Biology
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2009
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Prenatal choline availability modulates hippocampal and cerebral cortical gene expression
Dietary choline deficiency alters global and gene‐specific DNA methylation in the developing hippocampus of mouse fetal brains
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