Gestation-Specific Changes in the Anatomy and Physiology of Healthy Pregnant Women: An Extended Repository of Model Parameters for Physiologically Based Pharmacokinetic Modeling in Pregnancy

@article{Dallmann2017GestationSpecificCI,
  title={Gestation-Specific Changes in the Anatomy and Physiology of Healthy Pregnant Women: An Extended Repository of Model Parameters for Physiologically Based Pharmacokinetic Modeling in Pregnancy},
  author={Andr{\'e} Dallmann and Ibrahim Ince and Michaela Meyer and Stefan Willmann and Thomas Eissing and Georg Hempel},
  journal={Clinical Pharmacokinetics},
  year={2017},
  volume={56},
  pages={1303-1330}
}
BackgroundIn the past years, several repositories for anatomical and physiological parameters required for physiologically based pharmacokinetic modeling in pregnant women have been published. While providing a good basis, some important aspects can be further detailed. For example, they did not account for the variability associated with parameters or were lacking key parameters necessary for developing more detailed mechanistic pregnancy physiologically based pharmacokinetic models, such as… CONTINUE READING
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Translational Systems Pharmacology Studies in Pregnant Women

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